Description_x000D_ General description_x000D_ Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis._x000D_ Physical form_x000D_ Lyophilized from 0.2 μm-filtered solution in PBS._x000D_ Reconstitution_x000D_ Reconstitute with 100 μL deionized water._x000D_ Other Notes_x000D_ Signal peptide and rat progranulin (aa 1-602) are fused at the C-terminus to a FLAG®-tag._x000D_ Legal Information_x000D_ FLAG is a registered trademark of Sigma-Aldrich Co. LLC