Description_x000D_ General description_x000D_ Recombinant Human PTHrP is a 9.8 kDa protein consisting of 86 amino acid residues._x000D_ Application_x000D_ The human parathyroid hormone-like related protein (PTHrP) has been used as an osteoarthritis-associated factor regulating hypertrophic differentiation of human chondrocytes. It has also been used in the regulation of the expression of Smpd3 (Sphingomyelin phosphodiesterase 3) in chondrocytes._x000D_ Biochem/physiol Actions_x000D_ The gene PTHrP (parathyroid hormone-like related protein) encodes a protein involved in skeletal development. It binds to the receptor activated by PTH (parathyroid hormone) and functions in smooth muscle relaxation, regulation of cellular proliferation and differentiation. It also regulates endochondral bone development and proliferation of growth plate chondrocytes. It regulates fetal blood calcium and placental calcium transport. It has been associated with malignant hypercalcemia. Mutation in this gene has been associated with brachydactyly type E2 (BDE2)._x000D_ Physical form_x000D_ Sterile filtered and lyophilized without additives._x000D_ Reconstitution_x000D_ Centrifuge the vial prior to opening. Avoid freeze-thaw cycles._x000D_ Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.