Description_x000D_ General description_x000D_ Anti-c-Jun N-Terminal Kinase (JNK1, JNK2) is developed in rabbit using a synthetic peptide, corresponding to amino acids of human c-Jun N-terminal kinase 1 (JNK1), coupled to KLH as the immunogen._x000D_ JNK (c-Jun N terminal protein kinase, also known as stress activated protein kinase, SAPK1) is a protein that belongs to serine/threonine-protein kinase family. It has a critical role in inhibiting WOX1 (WW domain-containing oxidoreductase) mediated apoptosis. It also mediates starvation-induced BCL2 phosphorylation and activates autophagy. Anti-c-Jun N-terminal kinase antibody can be used in microarray. Rabbit anti-c-Jun N-terminal kinase antibody reacts specifically with JNK1 (46 kD) and JNK2 (55 kD) of cell culture lysates and rat brain tissue extracts. The product has also shown weak cross reactivity for JNK2β (50 kD) isoform in mouse NIH-3T3 fibroblast cell lysate._x000D_ Immunogen_x000D_ Synthetic peptide corresponding to amino acids 339-354 of human JNK1 (c-Jun N-terminal kinase 1), conjugated to KLH. The sequence is highly conserved in JNK1, JNK2 α, β, γ (p54 SAPK α, β, γ) and identical in human, rat, and mouse JNK1._x000D_ Application_x000D_ Anti-c-Jun N-Terminal Kinase antibody produced in rabbit has been used in western blotting._x000D_ Disclaimer_x000D_ Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals._x000D_ Biochem/physiol Actions_x000D_ Mitogen-activated protein kinases (MAPKs) are serine/threonine kinases which play a central role in mitogenic signaling. The MAPKs function to transduce extracellular signals to intracellular targets, including transcription factors controlling the expression of genes essential to many cellular processes including proliferation, development and differentiation. JNK1 is essential for tumor necrosis factor alpha (TNF-α)-induced c-Jun kinase activation, c-Jun expression, and apoptosis. JNK1 and JNK2 participates in the survival of neuronal cells.