Description_x000D_ General description_x000D_ The Rat IL-1 β ELSA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Rat IL-1β cell lysate and tissue lysate._x000D_ Immunogen_x000D_ Recombinant Rat IL-1 β_x000D_ Application_x000D_ For research use only. Not for use in diagnostic procedures_x000D_ Rat IL-1 Β ELISA Kit has been used to measure IL-1 Β levels ._x000D_ Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)_x000D_ Biochem/physiol Actions_x000D_ Pro-inflammatory cytokine IL-1 Β (IL1B), which is highly expressed on Β-adrenoreceptor in obese adipose tissues, is implicated in induction of uncoupling protein 1 (UCP1) expression via extracellular signal-regulated kinase (ERK) activation in adipocytes. Macrophage autophagy inhibits the production of inflammasome-dependent IL-1Β and thereby it plays a vital role in reducing acute toxin-induced liver injury and death. In rats, IL-1Β enhanced neurogenesis and plasticity of carotid bodies (CB) by triggering ERK1/2 activation. IL-1Β plays a vital role in alteration of glomerular hemodynamics via stimulating the production of prostaglandin E2 (PGE2) in the mesangial cells._x000D_ Other Notes_x000D_ A sample Certificate of Analysis is available for this product._x000D_ Please type the word sample in the text box provided for lot number.