Description_x000D_ General description_x000D_ The gene encoding RB transcriptional corepressor 1 (RB1) is a tumor suppressor gene localized on human chromosome 13q14.2._x000D_ Biochem/physiol Actions_x000D_ RB transcriptional corepressor 1 (RB1) modulates the cell cycle. It acts as a repressor of transcription mediated by E2 factor (E2F) and influences transcriptional silencing. RB1 modulates mitochondrial activities and has a role in the organization of heterochromatin. Mutations in the gene encoding this protein have been associated with childhood retinoblastoma._x000D_ Physical form_x000D_ Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol._x000D_ Preparation Note_x000D_ after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles