Description General description A cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC50 = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404). A cell-permeable inhibitor of RNA polymerase III (RNA Pol III) (IC50 = 27 µM for human RNA Pol III and 32 µM for Saccharomyces cerevisiae RNA Pol III). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Packaging 10 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target activity against RNA Polymerase III Product does not compete with ATP. Reversible: no Target IC50: 27 and 32 µM for Human and S. cerevisiae RNA Pol III Packaging Packaged under inert gas Warning Toxicity: Carcinogenic / Teratogenic (D) Preparation Note Slight warming may be necessary to achieve complete solubilization. Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Other Notes Wu, L., et al. 2003. Euk. Cell2, 256.