Description_x000D_ General description_x000D_ Rolipram enhances tissue protection, anatomical repair and functional recovery. It is used to treat asthma, arthritis, Huntington′s disease and multiple sclerosis. Rolipram inhibits injury-induced reductions in cyclic AMP, which is associated with acute central nervous system injury. It functions as an antidepressant, stimulates neurite outgrowth and axonal regeneration in the presence of myelin inhibitors._x000D_ Application_x000D_ Rolipram has been used:_x000D_ • to investigate its effects on testicular torsion–detorsion injury(36)_x000D_ • to block the effects of phosphodiesterase-4 (PDE4)(37)_x000D_ • as a component in chemically induced long-term potentiation (cLTP) induction media(38)_x000D_ Packaging_x000D_ 10 mg in glass bottle_x000D_ 25, 100 mg in poly bottle_x000D_ Biochem/physiol Actions_x000D_ Selective cAMP-specific phosphodiesterase (PDE4) inhibitor._x000D_ Features and Benefits_x000D_ This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm._x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here._x000D_ Legal Information_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC