Description General description Native homodimeric S-100b isoform composed of ββ-subunits, purified from bovine brain. Elevated serum level of S-100b is used as a marker of stroke and cerebral edema. The homodimeric S-100 isoform composed of ββ-subunits, purified from bovine brain. The S-100 proteins are acidic Ca2+ binding proteins found predominately in glial cells. Evidence indicates that upon binding to Ca2+, S-100 proteins expose a hydrophobic domain to the solvent in a manner similar to calmodulin. Within the cell, S-100 proteins have been reported to regulate adenylate cyclase, aldolase activities, ATPase, microtubules, and protein phosphorylation. Under nonreducing conditions both the dimeric and monomeric forms may be visible. Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock. Packaging 1 mg in Plastic ampoule Warning Toxicity: Standard Handling (A) Physical form Lyophilized from 50 mM Tris-HCl, pH 7.5, 50 mM NaCl, 100 µM DTT. Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Other Notes Momotani, E., et al. 1993. J. Comp. Pathol. 108, 291. Baudier, J., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 11627. Donato, R. 1991. Cell Calcium12, 713. Isobe, T., et al. 1977. Biochim. Biophys. Acta494, 222.