Description_x000D_ General description_x000D_ The APP (amyloid precursor protein) gene is mapped to human chromosome 21q21.3. It encodes a integral membrane protein. APPα is a soluble protein generated by sequential cleavage with α and γ secretase._x000D_ Application_x000D_ Human amyloid precursor protein α secreted, has been used in enzyme linked immunosorbent assay (ELISA)._x000D_ Biochem/physiol Actions_x000D_ Amyloid precursor protein α is an α-secretase-cleaved soluble protein that has been shown to have neuroprotective properties. It is derived from amyloid precursor protein. The protein consists of 612 amino acids. Several G protein-coupled receptors are known to activate α-secretase-dependent processing of APP. It has neuroprotective, neurogenic and neurotrophic functions. Amyloid precursor protein a also stimulates gene expression and protein expression._x000D_ Physical form_x000D_ Solution 0.2 μm filtered, in phosphate buffered saline, pH 7.4._x000D_ Preparation Note_x000D_ Expressed as a soluble protein and purified under non-denaturing conditions.