Description_x000D_ General description_x000D_ Sex hormone binding globulin (SHBG) is secreted by the liver. It is also expressed in the endometrium, ovary and testis. SHBG is composed of 402 amino acids and the gene encoding it is localized on human chromosome 17p12–p13._x000D_ Application_x000D_ Sex hormone binding globulin (SHBG) from human serum has been used to study the effects of hydroxylated estrogen metabolites (2-OH-E2 and 4-OH-E2) on the mRNA and protein expression of SHBG in MCF-7 human breast cancer cell line._x000D_ Biochem/physiol Actions_x000D_ Sex hormone binding globulin (SHBG) is a dimeric plasma glycoprotein with high affinity for the gonadal steroids, testosterone and estradiol. It regulates the availability of sex steroid hormones and limits their access to target cells. SHBG also inhibits estradiol-induced proliferation of breast cancer cells. Alterations in the expression of the protein have been linked to male infertility._x000D_ Physical form_x000D_ Solution in 20 mM Tris-HCl, 10% Glycerol, pH 7.4