Description_x000D_ Packaging_x000D_ 5, 25 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ DAT is crucial for regulating the levels of DA (dopamine). It is also responsible for the reuptake of 1-methyl-4-phenylpyridinium (MPP+), neurotoxin which mediates symptoms similar to Parkinson’s disease. Changes in DAT activity is associated with attention-deficit/hyperactivity and autism spectrum disorders._x000D_ SRI-29574 is a potent DAT (dopamine transporter) allosteric modulator that partially inhibits DAT uptake without affecting binding to DAT. SRI-29574 is a noncompetitive inhibitor of [3H]DA uptake. Also SRI-29574 partially inhibits SERT and NET uptake.