Description_x000D_ General description_x000D_ Chemical structure: indol derivative_x000D_ Application_x000D_ Staurosporine from Streptomyces sp. was used to induce cell death in MDCK, 293T, Vero, HeLa, and Swiss Webster primary macrophage cells.5 It was used to study the effect of caspase activation on human sperm quality.6_x000D_ Packaging_x000D_ 0.1, 0.5, 1 mg in serum bottle_x000D_ Biochem/physiol Actions_x000D_ Partially reverses MDR, sensitizing cells with MDR phenotype to cytotoxic agents. Inhibits Pgp phosphorylation. However, functional significance of Pgp phosphorylation is ill defined._x000D_ Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells._x000D_ Features and Benefits_x000D_ This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm._x000D_ Analysis Note_x000D_ Tested for inhibition of interleukin 2 production in Jurkat cells.