Description_x000D_ General description_x000D_ Streptozocin or streptozotocin, is obtained from Streptomyces achromogenes. Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells._x000D_ Application_x000D_ Streptozocin or streptozotocin is used to induce type 1 diabetes for medical research._x000D_ Packaging_x000D_ 1, 5 g in glass bottle_x000D_ 50, 100, 500 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage. Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter._x000D_ Clinically, the chemical is used for the treatment of pancreatic β cell carcinoma._x000D_ Features and Benefits_x000D_ This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here._x000D_ Other Notes_x000D_ Mixed anomers