Description_x000D_ Application_x000D_ SU 11274 was used to inhibit c-Met in non-small cell lung cancer cell lines.3_x000D_ SU11274 has been used:_x000D_ • To study the role of hepatocyte growth factor (HGF) in human vestibular schwannoma proliferation._x000D_ • To study its effect on human gastric carcinoma cell line MKN-45._x000D_ • To study the effect of HGF on phosphorylation of epidermal growth factor receptor, c-Met and other signaling pathways._x000D_ Biochem/physiol Actions_x000D_ SU 11274 is a class I c-Met inhibitor that competes with ATP to bind to the activation loop of c-Met.1 Inhibition of c-Met by SU 11274 is effective in improving the clinical outcome in non-small cell lung cancer cell lines.2_x000D_ c-Met kinase is a hepatocyte growth factor, involved in tumor invasion process and thus it serves as therapeutic target for cancer. It is found that SU11274 showed decreased tumor progression in human melanoma, by reducing tumor growth and metastasis._x000D_ SU 11274 is a Met tyrosine kinase inhibitor._x000D_ Features and Benefits_x000D_ This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm._x000D_ This compound is featured on the Met page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.