Description General description A potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor. Inhibits Src (IC50 = 280 nM) as well as closely related kinases such as Fyn (IC50 = 170 nM) and Yes (IC50 = 20 nM) and Lyn (IC50 = 130 nM). Acts as a weak inhibitor of Lck (IC50 = 688 µM) and PDGF receptor kinase (IC50 >10 µM). A 10 mM (500 µg/135 µl) solution of SU6656 (Cat. No. 572636) in DMSO is also available. A potent, cell-permeable, reversible, and ATP-competitive inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC50 = 280 nM) as well as closely related kinases Fyn (IC50 = 170 nM), Yes (IC50 = 20 nM) and Lyn (IC50 = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC50 = 6.88 µM). Does not affect the activity of PDGF-β receptor kinase (IC50 ≥10 µM) and IGF-1 receptor kinase (IC50 ≥20 µM). Packaging 1 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Product competes with ATP. Reversible: yes Target IC50: 280 nM, 170 nM, 20 nM, and 130 nM against Src, Fyn, Yes, and Lyn. Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Other Notes Bowman, T., et al. 2001. Proc. Natl. Acad. Sci. USA98, 7319. Blake, R.A., et al. 2000. Mol. Cell. Biol.20, 9018.