Description_x000D_ Packaging_x000D_ 10 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ TAS-301 is known to block intimal thickening post balloon injury in rat carotid arteries. It inhibits intimal thickening by blocking Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) and cytoskeletal depolymerization. Moreover, TAS 301 can also inhibit receptor-regulated influx of calcium in rat vascular smooth muscle cells (VSMCs)._x000D_ Inhibitor of migration and proliferation in vascular smooth muscle cells; inhibitor of restenosis._x000D_ Preparation Note_x000D_ TAS-301 is soluble in DMSO at 40 mg/ml.