Description General description tBuXPhos [2-Di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. Application tBuXPhos has been used in the preparation of [tBuXPhosAu(MeCN)]BAr4F, a gold catalyst for the intermolecular [2+2] cycloaddition of terminal arylalkynes with substituted alkenes to form functionalized cyclobutenes with high regioselectivity. tBuXPhos is a ligand for Pd-catalyzed C-O and C-N bond formation. It can be used in the following reactions: • Palladium-catalyzed Tsuji-Trost substitution and cross-coupling of benzylic fluorides. • Palladium-catalyzed C-N cross-coupling of sulfinamides and aryl halides. • Palladium-catalyzed rapid methoxylation and deuteriomethoxylation of bromo-chalcones. Packaging 1, 5, 25, 100, 500 g in glass bottle Legal Information Usage subject to Patents: EP 1097158; JP 5758844; CA 2336691