Description General description A cell-permeable, bis-catechol containing, m-phenylenediamide compound that displays anti-proliferative properties. Acts as a potent, reversible inhibitor of telomerase activity (IC50 = 670 nM, TRAP lysate prepared from U937 cells). Prolonged treatment with MST-312 has been reported to result in telomere shortening and growth arrest in U937 cells. Does not inhibit the activity of Taq DNA polymerase (IC50 >3 µM). Packaging 10 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target TRAP lysate prepared from U937 cells Product does not compete with ATP. Reversible: yes Target IC50: 670 nM against telomerase activity in TRAP lysate prepared from U937 cells Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Reconstitution Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Other Notes Seimiya, H., et al. 2005. Cancer Cell7, 25. Seimiya, H., et al. 2002. Mol. Cancer Ther.1, 657.