Description General description Caution: may contain trace amounts of intact toxin. The C-terminal binding portion of the chain of tetanus toxin. The intact toxin is known to block neurotransmitter release at inhibitory synapses in cultured spinal cord cells. Shows trans-synaptic retrograde transport in the central nervous system. Caution: may contain trace amounts of intact toxin. Follow the handling procedure described in the information that accompanies the product. The C-terminal binding portion of the heavy chain of tetanus toxin. Useful for binding studies. The C-terminal binding portion of the heavy chain of tetanus toxin. Packaging 10 μg in Alu drum Biochem/physiol Actions Primary Target Useful for binding studies Product does not compete with ATP. Warning Toxicity: Highly Toxic (H) Physical form Lyophilized from 10 mM sodium phosphate buffer, pH 7.5. Reconstitution Following reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Once an aliquot has been thawed, do not refreeze. Aqueous stock solutions are stable for 7-10 days at 4°C. Analysis Note Single major band by SDS-PAGE Other Notes Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. Poulain, B. 1994. Pathol. Biol. 42, 173. Williamson, L.C., et. al. 1993. Soc. Neurosci. 19, Abstract 770.10. Evinger, C. and Erichsen, J.T. 1986. Brain Res.380, 383. Helting, T.B. and Zwisler, O. 1977. J. Biol. Chem.252, 187. Matsuda, M. and Yoneda, M. 1977. Biochem. Biophys. Res. Commun.77, 268.