Description_x000D_ Application_x000D_ TG003 has been used in PAC1 cell culture and in vitro kinase assays._x000D_ TG003 has been used to develop assays for screening substances that affect mRNA splicing1._x000D_ Packaging_x000D_ 5, 25 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ TG003 regulates alternative splicing and reduces the phosphorylation of SF2/ASF1._x000D_ TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy._x000D_ Potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk). Ki = 10 nM for mClk1/Sty; IC50 = 15 nM, 20 nM, 200 nM, and > 10 mM for mClk4, mClk1, mClk2, and mClk3, respectively._x000D_ Features and Benefits_x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ Packaging_x000D_ Packaged under nitrogen._x000D_ Preparation Note_x000D_ TG003 is soluble in DMSO at 33 mg/ml._x000D_ Legal Information_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC