Description General description A potent inhibitor of human telomerase (IC50 = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces highly in the presence of quadruplex DNA. A potent inhibitor of human telomerase (IC50 = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces intensely in the presence of quadruplex DNA. Packaging 25 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: no Product does not compete with ATP. Reversible: no Target IC50: 6.5 µM inhibiting human telomerase Warning Toxicity: Standard Handling (A) Other Notes Yamashita, T., et al. 2005. Bioorg. Med. Chem.13, 2433. Izbicka, E., et al. 1999. Cancer Res. 59, 639. Anantha, N.V., et al. 1998. Biochemistry 37, 2709. Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724. Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261.