Description General description A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC50 = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effect of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells. A cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC50 = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effects of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells. Packaging 5 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target Acetyl-CoA carboxylase (ACC) Product competes with ATP. Reversible: yes Target IC50: 4 µM inhibiting cellular fatty acid synthesis in human breast cancer cell line MCF7 Packaging Packaged under inert gas Warning Toxicity: Carcinogenic / Teratogenic (D) Preparation Note Slight warming and sonication may be required for complete solubilization in ethanol. Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Other Notes Landree, L.E., et al. 2004. J. Biol. Chem.279, 3817. Zhou, W., et al. 2003. Cancer Res.63, 7330. Hu, Z., et al. 2003. Proc. Natl. Acad. Sci. USA100, 12624. Pizer, E.S., et al. 2000. Cancer Res.60, 213. Arbeeny, C.M., et al. 1992. J. Lipid Res.33, 843. Fukuda, N. and Ontko, J.A. 1984. J. Lipid Res.25, 831.