Description_x000D_ Application_x000D_ Tolvaptan has been used as a V2-selective antagonist for studying its effect on hypertension in mice._x000D_ Packaging_x000D_ 5, 25 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Tolvaptan (OPC 41061) is a potent, orally active non-peptide vasopressin V2 selective antagonist. IC50 = 3 nM at the rat V2 receptor; 29 times more selective for the V2 than for V1a. Tolvaptan has also been shown to inhibit the development of polycystic kidney disease in several animal models._x000D_ Features and Benefits_x000D_ This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here._x000D_ Preparation Note_x000D_ Tolvaptan is soluble in DMSO at a concentration that is greater than or equal to 15 mg/ml.