Description General description trans-1-methoxy-3-trimethylsiloxy-1,3-butadiene is a funtionalized Diels-Alder diene. Mukaiyama-Michael-type addition/heterocyclization of trans-1-methoxy-3-trimethylsiloxy-1,3-butadiene (Danishefsky′s diene) with 1,2-diaza-1,3-butadiene has been investigated. Asymmetric hetero-Diels-Alder cyclization of Danishefsky′s diene with benzaldehyde catalyzed by mesoporous inorganic/metalorganic hybrid materials has been reported. Application trans-1-Methoxy-3-trimethylsiloxy-1,3-butadiene was used: • in the synthesis of sulfone analogues of griseofulvin (sulfogriseofulvins), 4H-1-aminopyrroles and 4,5H-pyrazoles • as Diels-Alder diene for the synthesis of pyridones and pyranones • as reagent employed in the Mannich-Michael reaction for preparation of piperidinones and enaminones Packaging 1, 5 g in ampule