Description General description Trimethyl(trifluoromethyl)silane (TMSCF3) is also called as Ruppert-Prakash fluorination reagent. It is extensively used for the synthesis of trifluoromethyl-containing compounds. Application Reactant for: • Silver-mediated C-H trifluoromethylation of arenes • Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 8 • Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts • Palladium-catalyzed oxidative trifluoromethylation of indoles • Preparation of 5-HT1A antagonists • Used as difluorocarbene source TMSCF3 can be used as a reagent for: • Conversion of aromatic aldehydes to difluoromethylated products. • C-H trifluoromethylation of arenes, terminal alkynes, tertiary amines, heteroarenes, allylic, and terminal alkenes using metal catalyst or metal free oxidative trifluoromethylation reaction. It can also be used in trifluoromethylation of: • Non-activated aldimines. • Heterocumulenes. • Azomethine imines. Packaging 10, 50 mL in glass bottle