Description General description Trimethylpentafluoroethylsilane ((Pentafluoroethyl)trimethylsilane) is a perfluoroalkylsilane. Alkyl triflates undergo nucleophilic pentafluoroethylation with trimethylpentafluoroethylsilane to form the corresponding pentafluoroethylated alkanes. Application Trimethylpentafluoroethylsilane has been reported as a Ruppert-Prakash type reagent for the addition of pentafluoroethane. Recent report by Larionov and coworkers displayed the feasibility of adding pentrafluoroethane to N-heterocycles under basic conditions. Trimethylpentafluoroethylsilane ((Pentafluoroethyl)trimethylsilane) may be used as a perfluoroalkylating reagent for the synthesis of the following quinoline derivatives: • 5-bromo-2-(perfluoroethyl)quinoline • 8-methoxy-2-(perfluoroethyl)quinoline • 1-(perfluoroethyl)isoquinoline • 8-(tert-butoxy)-5,7-dichloro-2-(perfluoroethyl)quinolone It may also be used in the synthesis of pentafluoroethylcyclohexanes. Packaging 1, 10 g in glass bottle Legal Information Synthetic and mechanistic aspects of the regioselective base-mediated reaction of perfluoroalkyl- and perfluoroarylsilanes with heterocyclic N-oxides