Description General description (Trimethylsilyl)diazomethane is considered as a non-explosive substitute to diazomethane for the homologation of carbonyl derivatives, mainly ketones, via reactions such as Tiffeneau-Demjanov rearrangement. Application Reactant for preparation of: • Macrolactam analogs of the natural product macrolide (-)-A26771B with improved metabolic stability and antibacterial activity • Aigialomycin D analogues as protein kinase inhibitors for cancer treatment • Unnatural α-amino acid derivatives containing gem-bisphosphonates via Michael addition reaction • Capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates • Stictamides A-C as matrix metallopeptidase 12 (MMP12) inhibitors with antitumor invasion activity • Endothelin converting enzyme (ECE) Inhibitors WS 75624A and WS 75624B via a cross-metathesis approach • Ent-kaurene derivatives as anti-inflammatory agents • Desmosdumotin C analogs as potent antitumor agents acting via activation of spindle assembly checkpoint • Imidazolo[2,1-b]benzothiazole derivatives as potential p53 inhibitors Packaging 1 L in Sure/Seal™ 5, 25, 100 mL in Sure/Seal™