Description General description A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-α-induced apoptosis, and inhibits TNF-α-induced activation of NF-κB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1). A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells, sensitizes tumor cells to TNF-α-induced activation of NF-κB. Also inhibits IL-2 expression in activated T-cells at the level of purine-box/nuclear factor and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1). Reported to induce apoptosis by activating DEVD-cleaving caspases. Packaging 1, 5 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: no Primary Target Activate DEVD-cleaving caspases Product does not compete with ATP. Reversible: no Packaging Packaged under inert gas Warning Toxicity: Harmful & Carcinogenic / Teratogenic (E) Other Notes Zhao, Q., et al. 2005. J. Biol. Chem.280, 8101. Shepherd, E., et al. 2004. J. Biol. Chem.279, 54023. Chan, M.A., et al. 1999. Phytother. Res. 13, 464. Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451. Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443. Yang, Y., et al. 1998. Immunopharmacology40, 139.