Description General description A cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC50 = 4.5 µM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI50<10 nM for 46 lines among a 53 NCI panel tested). A cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC50 = 4.5 µM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI50<10 nM for 46 lines among a 53 NCI panel tested). Packaging 5 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target Purified porcine brain tubulin Product does not compete with ATP. Reversible: no Target IC50: 4.5 µM in inhibiting polymerization of purified porcine brain tubulin Packaging Packaged under inert gas Warning Toxicity: Harmful (C) Reconstitution Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Other Notes Pandit, B., et al. 2006. Bioorg. Med. Chem.14, 6492. Li, P.K., et al. 2005. Bioorg. Med. Chem. Lett.15, 5382.