Description_x000D_ General description_x000D_ UPK3A is a member of the uroplakin-3 family. Uroplakins (UP) which are transmembrane proteins are important components of the urothelium that pass the lipid bilayer once (UPII, UPIIIa, and UPIIIb) or four times (UPIa and UPIb; both members of the "tetraspanin" family). All hold great luminal/extracellular domains, but only UPIIIa and UPIIIb have significant cytoplasmic shares in their C-termini. UPK3A is an extremely specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. Alterations in this gene are related to renal adysplasia._x000D_ Physical form_x000D_ Sterile filtered colorless solution of 0.25 mg/mL containing 20 mM Tris-HCl buffer (pH 8.0), 150 mM NaCl, 2 mM DTT and 20% glycerol.