Description General description A cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore of the mobile ion-carrier type that transports alkali metal ions across artificial or biological lipid membranes. Induces K+ conductivity in cell membranes at concentrations as low as 10-8 M. Often used in membrane electrode systems for determining K+ concentration. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation. A cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore that transports alkali metal ions across artificial or biological lipid membranes (Rb+ >K+ >Cs+ >Ag+ >NH4+ >Na+ >Li+). Induces K+ conductivity in cell membranes at concentrations as low as 10 nM. Because of its ability to affect membrane transport of K+ and to create a hydrophobic layer on solid electrodes, it is often used in membrane electrode systems for determining K+ concentration. Useful in studies of K+ transport in mitochondria. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation. Packaging 100 mg in Glass bottle 25 mg in Fibre carton Biochem/physiol Actions Cell permeable: no Primary Target NGF-induced neuronal differentiation Product does not compete with ATP. Reversible: no Warning Toxicity: Highly Toxic (H) Other Notes Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. Harada, H., et al. 1994. Biochim. Biophys. Acta1220, 310. Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12. Orlov, V.N., et al. 1994. FEBS Lett.345, 104. Acra, S., et al. 1993. Am. J. Physiol.264, G45. Cornet, M., et al. 1993. J. Membr. Biol.131, 55. Deckers, C.L., et al. 1993. Exp. Cell Res.208, 362. Dimroth, P., and Thomer, A. 1993. Biochemistry32, 1734. Opanasenko, V.K., et al. 1992. FEBS Lett.307, 280. Pape, P.C., et al. 1992. J. Physiol.449, 219. Ahmed, S., and Booth, I.R. 1983. Biochem. J.212, 105. Lerner, A., et al. 1982. FEBS Lett.146, 9.