Description General description A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC50 = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC50 = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death. Packaging 1, 5 mg in Plastic ampoule Biochem/physiol Actions Cell permeable: yes Primary Target A steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Product does not compete with ATP. Reversible: no Target IC50: 12 nM against angiogenesis in vitro by inhibiting HUVEC proliferation Packaging Packaged under inert gas Warning Toxicity: Carcinogenic / Teratogenic (D) Other Notes Mohan, R., et al. 2004. Angiogenesis7, 115. Jeyaprakasam, B., et al. 2003. Life Sci.74, 125. Devi, P.U., et al. 1995. Cancer Lett.95, 189. Kupchan, S.M., et al. 1969. J. Org. Chem.34, 3858.