Description_x000D_ Application_x000D_ XAV939 has been used in the inhibition_x000D_ • of tankyrase in neuroblastoma cell lines_x000D_ • of diphtheria toxin-like ADP-ribosyltransferases (ARTD) in medulloblastoma cells_x000D_ • of wnt signalling in human induced pluripotent stem cells (hiPSCs)_x000D_ Packaging_x000D_ 5, 25 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ XAV939 is a cell-permeable dihydrothiopyranopyrimidinol, which elicits anti-tumor functionality against colon, lung, breast and liver cancer. It binds to catalytic poly-ADP-ribose polymerase (PARP) domain of the tankyrase enzyme resulting in β-catenin destruction. It also inhibits tankyrase in neuroblastoma promoting apoptosis in tumor cells._x000D_ XAV939 is a Tankyrase inhibitor (thereby inhibiting Wnt / β-catenin signaling)_x000D_ Features and Benefits_x000D_ This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm._x000D_ Other Notes_x000D_ XAV939 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the XAV939 probe summary on the Chemical Probes Portal website.