Description_x000D_ General description_x000D_ Y-27632 dihydrochloride is an effective bronchodilator and improves lung resistance (RL) induced by antigen and acetylcholine. Y-27632 controls neutrophil migration and lung edema and may be a potential drug for treating acute lung injury._x000D_ Application_x000D_ Y-27632 dihydrochloride has been used:_x000D_ • as a medium supplement in pancreatic ductal adenocarcinoma organoid culture_x000D_ • in the inhibition of Ras homolog gene family (Rho) kinase in mouse embryonic stem cells_x000D_ • in the inhibition of Rho-associated protein kinase (ROCK) in human embryonic stem cells and human induced pluripotent stem cells (iPSCs)_x000D_ Packaging_x000D_ 1, 5 mg in glass bottle_x000D_ Biochem/physiol Actions_x000D_ Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP._x000D_ Features and Benefits_x000D_ This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm._x000D_ This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more._x000D_ Legal Information_x000D_ Sold under license from Mitsubishi Pharma Corporation_x000D_ LOPAC is a registered trademark of Sigma-Aldrich Co. LLC